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Echinacoside

Intervention

1 paper3 findings

PubChem 5281771ChEBI 4745MeSH C060297

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Cells1

Outcomes

3

Oxidative stress and ROS signalling

downin cells1

1 study

  1. Echinacoside decreases oxidative stress and ROS signalling in cells.

    “downregulating the DNA damage marker γ-H2AX, thereby alleviating oxidative stress and enhancing genomic stability.”

    Cellsin aging oocytes

    Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

    Cell proliferation18 Apr 2025

More on Oxidative stress and ROS signalling

Reactive oxygen species

downin cells1

1 study

  1. Echinacoside decreases reactive oxygen species in cells.

    “It also preserved mitochondrial function by restoring membrane potential and dynamics, reducing ROS levels, and downregulating the DNA damage marker γ-H2AX”

    Cellsin aging oocytes

    Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

    Cell proliferation18 Apr 2025

More on Reactive oxygen species

Cytoskeletal stability

upin cells1

1 study

  1. Echinacoside improves cytoskeletal stability in cells.

    “ECH significantly improved cytoskeletal stability and chromosomal integrity, as demonstrated by restored spindle morphology and reinforced F-actin structures”

    Cellsin aging oocytes

    Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

    Cell proliferation18 Apr 2025

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