Donation after circulatory death

Donation after circulatory death has been studied in 4 papers since 2026: 1 observational study in people, 3 reviews; 4 in the past year. The newest story, Nov 12, 2026: “Donor type linked to distinct gene activity in human livers”.

Exposure

4 papers study it1 findingUpdated Nov 11, 2026

3 new papers in 30 daysSee all 4 papers on donation after circulatory death

At a glance

The findings reach people, from one lab or study. 1 lab.

“Immunohistochemistry showed a higher proportion of p16‐positive nuclei in high‐risk DCD livers compared with DBD livers ( p = 0.038)”

Transcriptomic Characterization of Cellular Senescence in Human Donor Livers Before TransplantationAging cell2026doi:10.1111/acel.70828

1 lab

Humans1

What did studies of donation after circulatory death find?

Studies of donation after circulatory death measured one outcome, Donor pool size.

Donor pool size

upin humans1+25%

1 study

Donation after circulatory death increases donor pool size in humans (implementation facilitated by machine perfusion) (up to 25%).
“donation after circulatory death (DCD) pathway which has increased donor pools by up to 25%”
Reviewimplementation facilitated by machine perfusionheart
From ice to innovation: the evolution of heart preservation methods
Frontiers in cardiovascular medicineOct 30, 2026

What is donation after circulatory death linked with?

Studies link donation after circulatory death with P16-positive nuclei.

P16-positive nuclei

upin humans1

1 study

Donation after circulatory death is associated with P16-positive nuclei in humans (high-risk DCD livers compared with DBD livers).
“Immunohistochemistry showed a higher proportion of p16‐positive nuclei in high‐risk DCD livers compared with DBD livers ( p = 0.038)”
Humanshigh-risk DCD livers compared with DBD liversliver
Donor type linked to distinct gene activity in human livers
Aging cellNov 11, 2026

Latest

4 papers in 12 months

Aging CellNov 12

Donor type linked to distinct gene activity in human livers

Activity of 1,548 genes differed between livers donated after brain death and circulatory death, including patterns linked to senescence, when cells stop dividing.Activity of 1,548 genes differed between livers donated after brain death and circulatory death, including patterns linked to senescence, when cells stop dividing.

Cross-sectional · 66 peopleMechanisms