End-stage heart failure

There are 9 papers on end-stage heart failure in aging research: 5 observational studies in people, 1 in animals, 3 reviews. The newest story, Nov 7, 2026: “Gene therapy extended life in mice with inherited heart disease”.

Disease

9 papers study it21 more mention it1 finding

4 new papers in 30 daysSee all 30 papers on end-stage heart failure

  • Humans5
  • Animals1

Associations

1

Cellular senescence

upin human cells1

1 study
  1. Cellular senescence is associated with end-stage heart failure in human cells (cardiac pericytes isolated from patients).

    “it was able to detect senescence in cardiac pericytes isolated from the hearts of patients affected by end-stage heart failure.”

    Cellscardiac pericytes isolated from patientsheart

    Simple Detection of Unstained Live Senescent Cells with Imaging Flow Cytometry

    Cells

More on Cellular senescence

Trial sponsors

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Dec 2025: 0Jan 2026: 1Feb 2026: 2Mar 2026: 3Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 1Oct 2026: 3Nov 2026: 112 papers in 12 months
AHA Scientific Sessions 2026 Abstract

Gene therapy extended life in mice with inherited heart disease

Among male mice, 69% given gene therapy were alive at 270 days, while controls had a median survival of 197 days.Among male mice, 69% given gene therapy were alive at 270 days, while controls had a median survival of 197 days.

Mouse studyInterventions

See all 30 papers on end-stage heart failure