Aging Cell
Donor type linked to distinct gene activity in human livers
Activity of 1,548 genes differed between livers donated after brain death and circulatory death, including patterns linked to senescence, when cells stop dividing.Activity of 1,548 genes differed between livers donated after brain death and circulatory death, including patterns linked to senescence, when cells stop dividing.
Cross-sectional · 66 peopleMechanisms
Who was studied66 human donor livers, against brain-death donor livers
What changedGene activity differed between circulatory-death and brain-death donor livers, with 1548 genes showing different expression
The catchCirculatory-death donors were older, potentially confounding gene-activity differences