VCAM1
upin mice1
Dihydrotestosterone increases VCAM1 in mice.
“re-induced VCAM1 expression in YFP+/Pax7-/low/VCAM1- cells”
Animalsin YFP+/Pax7-/low/VCAM1- cellsskeletal muscle
eLife25 Mar 2026Preprint
Muscle regeneration
upin mice1
Dihydrotestosterone improves muscle regeneration in mice.
“DHT restored regenerative function in aged mice”
Animalsskeletal muscle
eLife25 Mar 2026Preprint
Inflammation
downin mice1
Dihydrotestosterone inhibits inflammation in mice.
“DHT treatment rejuvenates HGPS hearts, upregulates pathways linked to heart function and downregulates inflammatory responses”
Animalsin HGPS miceheart
DHT ameliorates cardiac aging in progeroid mice by XRCC4-mediated genome stabilization
Mechanisms of ageing and development3 Dec 2025
Cardiac function
upin mice1
Dihydrotestosterone improves cardiac function in mice.
“DHT administration reduces DNA damage accumulation and promotes structural and functional recovery in HGPS hearts.”
Animalsin HGPS miceheart
DHT ameliorates cardiac aging in progeroid mice by XRCC4-mediated genome stabilization
Mechanisms of ageing and development3 Dec 2025
DNA damage accumulation
downin mice1
Dihydrotestosterone decreases DNA damage accumulation in mice.
“DHT administration reduces DNA damage accumulation and promotes structural and functional recovery in HGPS hearts.”
Animalsin HGPS miceheart
DHT ameliorates cardiac aging in progeroid mice by XRCC4-mediated genome stabilization
Mechanisms of ageing and development3 Dec 2025
In a Swedish cohort, 5-ARI users had a 17% lower risk of laryngeal or hypopharyngeal squamous cell carcinoma than nonusers (adjusted hazard ratio, 0.83).In a Swedish cohort, 5-ARI users had a 17% lower risk of laryngeal or hypopharyngeal squamous cell carcinoma than nonusers (adjusted hazard ratio, 0.83).