Dietary spermidine intake
Dietary spermidine intake has been studied in 2 papers since 2016: 1 observational study in people, 1 in animals; 1 in the past year. The newest paper, Oct 26, 2026: “Dietary spermidine intake and skeletal muscle spermine/spermidine ratio are associated with peak oxygen consumption and whole-body composition in patients with coronary artery disease”.
2 papers study it3 findingsUpdated
1 new paper in 30 daysSee all 2 papers on dietary spermidine intake
At a glance
The findings reach people, from one lab or study. 2 independent labs in 2 countries.
“higher dietary spermidine intake was associated with higher peakVO2/kg (β=3.3 mL·kg−1·min−1; p<0.01)”
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Agence Nationale de la Recherche and others
- Humans1
- Animals1
What is dietary spermidine intake linked with?
3Studies link dietary spermidine intake with 3 measures, most often appendicular lean mass indexed to body mass index (1 study), peak oxygen uptake per kilogram body weight (1) and cardiovascular disease (1).
Appendicular lean mass indexed to body mass index
upin humans1
1 study
Appendicular lean mass indexed to body mass index
upin humans1
Dietary spermidine intake is associated with appendicular lean mass indexed to body mass index in humans (coronary artery disease; log-transformed dietary intake; adjusted for age and sex) (β=0.15; p<0.001).
“dietary spermidine intake and the intramuscular spermine/spermidine ratio were associated with higher peak VO2/kg, higher ALM/BMI and lower body fat percentage.”
Humanscoronary artery disease; log-transformed dietary intake; adjusted for age and sex80% mensn = 180
ESC Congress 2026 abstract
Peak oxygen uptake per kilogram body weight
upin humans1
1 study
Peak oxygen uptake per kilogram body weight
upin humans1
Dietary spermidine intake is associated with peak oxygen uptake per kilogram body weight in humans (coronary artery disease; log-transformed dietary intake; adjusted for age and sex) (β=3.3 mL·kg−1·min−1; p<0.01).
“higher dietary spermidine intake was associated with higher peakVO2/kg (β=3.3 mL·kg−1·min−1; p<0.01)”
Humanscoronary artery disease; log-transformed dietary intake; adjusted for age and sex80% mensn = 180
ESC Congress 2026 abstract
Cardiovascular disease
downin humans1
1 study
Cardiovascular disease
downin humans1
Dietary spermidine intake is linked with a lower risk of cardiovascular disease in humans.
“high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease”
Humans
Cardioprotection and lifespan extension by the natural polyamine spermidine
Nature medicine