Global DNA methylation
5 papers3 findings
- Human trial2
- Humans2
Interventions
2Modified otago exercise program
no changein humans1
1 study
Modified otago exercise program
no changein humans1
Modified otago exercise program has no effect on global DNA methylation in humans.
“Intention-to-treat and per-protocol analyses revealed no statistically significant between-group differences in any biomarker.”
Human trialpeople living with dementia6 monthsn = 42
Molecular and cellular neurosciences18 Mar 2026
Diet and exercise
downin humans1
1 study
Diet and exercise
downin humans1
Diet and exercise decreases global DNA methylation in humans (BL: 0.54 ± 0.03 vs 12M: 0.45 ± 0.01, p=0.045).
“global DNA methylation (BL: 0.54 ± 0.03 Vs 6M: 0.51 ± 0.02, p=0.41) and BL: 0.54 ± 0.03 Vs 12M: ± 0.45± 0.01, p=0.045) in DNA samples”
Human trialsevere obesity with hypogonadismPBMC12 monthsmalesn = 64
ENDO 2025 abstract22 Oct 2025
Associations
1HIV infection
downin humans1
1 study
HIV infection
downin humans1
HIV infection is associated with global DNA methylation in humans.
“We found a strong association between HIV infection and global DNA hypomethylation”
Humansmales
Viruses2 Feb 2026
Latest
4 in 12 monthsMolecular and Cellular Neurosciences
Preliminary effects of a modified Otago Exercise Program on metabolic, cellular, and epigenetic biomarkers in people living with dementia: A pilot randomized controlled trial
Randomised trial in 42 peopleDementia
Viruses
HIV Infection as an Independent Factor Accelerating Epigenetic Ageing in Men Treated with Integrase Inhibitors: A Case-Control Study
Case-control study of 50 peopleHIV infection
Hypertension Research
Accelerated epigenetic age in hypertension: a systematic review and meta-analysis
Meta-analysis of observational studiesEpigenetic age
Biogerontology
Fins as a reliable surrogate tissue for age-related changes of telomeres and DNA methylation in gonads of a short-lived fish
Experiments in killifishBiomarkers
Frontiers in Immunology
Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases
ReviewImmune response
ENDO 2025 Abstract
MON-707 Lifestyle Intervention Therapy Modulates Global and Gene Specific DNA Methylation In Severely Obese Hypogonadal Men
Non-randomised trial in 116 peopleHypogonadism
Cell Death Discovery
The dark side of the light (UVA): melanoma microenvironment and cell survival strategies
Experiments in human cellsMechanisms