TNFRSF11A

1. TNFRSF11A induces IL-1β in mice.

   Animalsendothelial cells

   Endothelial RANK signaling triggers bone marrow inflammaging · Research Square · 4 Sep 2026 · Preprint

2. TNFRSF11A induces IL-1β in mice.

   “Bulk and single-cell RNA sequencing, and IL-1β neutralization demonstrate that RANK signaling induces IL-1β expression in endothelial cells, which in turn promotes bone marrow inflammaging.”

   Animalsendothelial cells

   Endothelial RANK signaling triggers bone marrow inflammaging through IL-1β expression · Research Square · 3 Sep 2026 · Preprint

IL-1β →

1. TNFRSF11A increases cellular senescence in mice.

   Animalsendothelial-specific deletionbone marrow

   Endothelial RANK signaling triggers bone marrow inflammaging · Research Square · 4 Sep 2026 · Preprint

2. TNFRSF11A increases cellular senescence in mice.

   “Endothelial-specific deletion of Tnfrsf11a (RANK), blockade of RANKL, and in vivo tracing with fluorescent-labelled RANKL revealed that RANK signaling in endothelial cells drives senescent cell accumulation in the bone marrow.”

   Animalsendothelial-specific deletion and blockadebone marrow

   Endothelial RANK signaling triggers bone marrow inflammaging through IL-1β expression · Research Square · 3 Sep 2026 · Preprint

Cellular senescence →