Stem Cell Research & Therapy·Nov 28Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotypeExperiments in miceOsteoarthritisPaper
International Journal of Molecular Sciences·Nov 27Senolytic Treatment Improves Responsiveness to Mechanical Loading in the Skeleton of Aged MiceExperiments in miceSenolyticsPaper
Aging and Disease·Nov 26Long-term Senolytic Treatment Prevents Endothelial Dysfunction in Arterial AgingExperiments in miceSenolyticsPaper
Frontiers in Cardiovascular Medicine·Nov 24Frailty and cardiovascular disease: a bidirectional relationship with clinical implicationsReviewMechanismsPaper
AHA Scientific Sessions 2025 Abstract·Nov 3Intestinal Microbiota-derived Phenylacetic acid Accelerates Perivascular Adipose Tissue Senescence and Atherosclerosis in AgingExperiments in miceCellular senescencePaper
Oncology Letters·Oct 29Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review)ReviewCellular senescencePaper
Frontiers in Immunology·Oct 23Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approachExperiments in miceMultiple sclerosisPaper
The American Journal of Sports Medicine·Oct 17Senolytic Combination of Dasatinib and Quercetin Promotes Tendon-to-Bone Healing by Mitigating Age-Related Senescence in RatsExperiments in 12 ratsSenolyticsPaper
Cell Biochemistry and Function·Oct 16Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes ProgressionExperiments in miceType 2 diabetesPaper
International Journal of Molecular Sciences·Oct 16Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung DiseasesReviewCellular senescencePaper
Circulation Research·Oct 15Vascular Niches Are the Primary Hotspots in Cardiac AgingExperiments in miceInterventionsPaper
Frontiers in Aging Neuroscience·Oct 13Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseasesReviewNeurodegenerative diseasePaper
Inflammopharmacology·Oct 11Targeting the senescence-associated secretory phenotype to modify osteoarthritis in agingReviewOsteoarthritisPaper
International Journal of Molecular Sciences·Sep 27SenolyticSynergy: An Attention-Based Network for Discovering Novel Senolytic Combinations via Human Aging GenomicsComputational studyAI & dataPaper
Journal of Alzheimer's Disease·Sep 22Advancing Alzheimer's disease treatment: A literature review on senolytic interventionReviewSenolyticsPaper
Frontiers in Microbiology·Sep 19Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiomeExperiments in miceDasatinib + quercetinPaper
Advanced Science·Sep 16Anti-Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc DegenerationExperiments in ratsIntervertebral disc degenerationPaper
bioRxiv·Sep 5Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing SenosensitizersPreprint: experiments in miceSenolyticsPaper
Particle and Fibre Toxicology·Sep 2Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J miceExperiments in miceInterventionsPaper
Molecular Diagnosis & Therapy·Aug 26Cardiovascular Aging: From Molecular Mechanisms to Targeted TherapiesReviewInterventionsPaper
International Journal of Molecular Sciences·Aug 14Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of ExerciseReviewExercisePaper
Fundamental Research·Aug 8Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone lossExperiments in miceSenolyticsPaper
Cardiology in Review·Aug 1Telomere Dynamics in Cardiovascular Aging: From Molecular Mechanisms to Precision MedicineReviewTelomerase and telomere maintenancePaper
Biomedicines·Jul 29Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related DiseasesReviewCellular senescencePaper
Placenta·Jul 28Investigating the abnormalities and potential therapeutic targets in umbilical cord mesenchymal stem cells from preeclampsiaStudy in peoplePreeclampsiaPaper
Alzheimer's Research & Therapy·Jul 28A human neuron alzheimer's disease model reveals barriers to senolytic translatabilityExperiments in human cellsSenolyticsPaper
Biochemical and Biophysical Research Communications·Jul 28Engineered bifunctional extracellular vesicles simultaneously promoting senolysis and efferocytosis for anti-aging therapy in diabetic miceExperiments in miceExtracellular vesiclesPaper
Clinical & Experimental Ophthalmology·Jul 15Novel Insight of Posterior Capsule Opacification: The Role of Lens Epithelial Cell SenescenceExperiments in rabbitsInterventionsPaper
npj Aging·Jul 12Nothobranchius furzeri: a vertebrate model for studying cardiac aging and cellular senescenceExperiments in killifishInterventionsPaper
bioRxiv·Jul 9Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in micePreprint: experiments in miceSenolyticsPaper