D-pinitol

1. D-pinitol extends lifespan in worms (+28.6% mean lifespan).

   “200 μM of DP increased mean lifespan of C. elegans by 28.6%”

   Model organisms200 μM

   D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling

   npj aging·27 Apr 2026

2. D-pinitol extends lifespan in worms.

   “In C. elegans, DP treatment enhanced lifespan, stress capacity, antioxidant capacity (T-SOD/CAT/GSH-Px/MDA/ROS), and altered aging-related indicators”

   Model organisms

   D-pinitol ameliorated H₂O₂-induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans

   Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·20 Sep 2023

1. D-pinitol activates autophagy in worms.

   “DP further enhanced HLH-30-dependent autophagy and mitophagy activities, which are essential for lifespan extension.”

   Model organismsHLH-30-dependent

   D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling

   npj aging·27 Apr 2026

More on Autophagy

1. D-pinitol decreases cellular senescence in mammals cells.

   “Moreover, DP suppressed cellular senescence in multiple mammalian cell types.”

   Cellsmultiple mammalian cell types

   D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling

   npj aging·27 Apr 2026

More on Cellular senescence

1. D-pinitol decreases proteotoxicity in worms.

   “DP also attenuated proteotoxicity and delays functional decline in C. elegans models of Parkinson's, Huntington's, and Alzheimer's diseases.”

   Model organismsModels of Parkinson's, Huntington's, and Alzheimer's diseases

   D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling

   npj aging·27 Apr 2026

1. D-pinitol improves locomotor function in worms.

   “200 μM of DP increased mean lifespan of C. elegans by 28.6%, as well as healthspan phenotypes including preserved locomotor function and delayed lipofuscin accumulation.”

   Model organisms200 μM

   D-pinitol extends the lifespan of Caenorhabditis elegans through integrated antioxidant defense, proteostasis, and autophagy signaling

   npj aging·27 Apr 2026

1. D-pinitol increases lean mass in mice (8.47 ± 0.81 g vs. 7.08 ± 1.64 g).

   “increased lean mass (8.47 ± 0.81 g vs. 7.08 ± 1.64 g)”

   Animalsin STZ-induced diabetic SAM-P8 mice150 mg/kg per day6 weeks

   The regulation of MFG-E8 on the mitophagy in diabetic sarcopenia via the HSPA1L-Parkin pathway and the effect of D-pinitol

   Journal of cachexia, sarcopenia and muscle·29 Mar 2024

1. D-pinitol increases muscle cross-sectional area in mice (1912.17 ± 535.61 μm2 vs. 1557.19 ± 588.38 μm2).

   “muscle cross-sectional area (CSA) (1912.17 ± 535.61 μm2 vs. 1557.19 ± 588.38 μm2)”

   Animalsin STZ-induced diabetic SAM-P8 micegastrocnemius muscle150 mg/kg per day6 weeks

   The regulation of MFG-E8 on the mitophagy in diabetic sarcopenia via the HSPA1L-Parkin pathway and the effect of D-pinitol

   Journal of cachexia, sarcopenia and muscle·29 Mar 2024

1. D-pinitol improves grip strength in mice (208.62 ± 39.45 g vs. 160.87 ± 26.95 g).

   “DP exerted protective effects on sarcopenia and mitophagy (DP + STZ-P8 vs. STZ-P8; all P < 0.01), such as increased lean mass (8.47 ± 0.81 g vs. 7.08 ± 1.64 g), grip strength (208.62 ± 39.45 g vs. 160.87 ± 26.95 g)”

   Animalsin STZ-induced diabetic SAM-P8 miceskeletal muscle150 mg/kg per day6 weeks

   The regulation of MFG-E8 on the mitophagy in diabetic sarcopenia via the HSPA1L-Parkin pathway and the effect of D-pinitol

   Journal of cachexia, sarcopenia and muscle·29 Mar 2024

1. D-pinitol decreases amyloid-beta toxicity in worms.

   “Moreover, DP could reduce the toxicity Aβ in transgenic C. elegans CL4176, CL2355, and CL2331.”

   Model organismsin transgenic C. elegans CL4176, CL2355, and CL2331

   D-pinitol ameliorated H₂O₂-induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans

   Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·20 Sep 2023