Curcumin analog C1
2 papers5 findings
- 2 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 3 more
- Animals2
Outcomes
4Autophagy
upin mice2
2 studies
Autophagy
upin mice2
Curcumin analog C1 activates autophagy in mice.
“in vivo treatment with the curcumin analog C1 (a TFEB activator) enhanced autophagic function in aging kidneys”
AnimalsLPS-induced acute kidney injurykidney
Aging cell21 Jul 2026
Curcumin analog C1 activates autophagy in mice.
“reversed the inhibition of transcription factor EB (TFEB) nuclear translocation, which was accompanied by the restoration of autophagic capability in OHCs of aged mice.”
Animalsin OHCs of aged miceouter hair cells
International immunopharmacology17 Jun 2025
Acute kidney injury
downin mice1
1 study
Acute kidney injury
downin mice1
Curcumin analog C1 decreases acute kidney injury in mice.
“in vivo treatment with the curcumin analog C1 (a TFEB activator) enhanced autophagic function in aging kidneys and reduced LPS-induced AKI.”
AnimalsLPS-induced acute kidney injurykidney
Aging cell21 Jul 2026
Oxidative stress and ROS signalling
downin mice1
1 study
Oxidative stress and ROS signalling
downin mice1
Curcumin analog C1 decreases oxidative stress and ROS signalling in mice.
“Furthermore, C1 exhibited an antioxidative effect in the OHCs of AHL mice.”
Animalsin the OHCs of AHL miceouter hair cells
International immunopharmacology17 Jun 2025
Age-related hearing loss
downin mice1
1 study
Age-related hearing loss
downin mice1
Curcumin analog C1 protects against age-related hearing loss in mice.
“C1 delayed AHL progression and mitigated the loss of OHCs in both aged C57BL/6 mice and aging cultured sensory epithelium explants.”
Animalsin aged C57BL/6 mice
International immunopharmacology17 Jun 2025