Sepsis-associated acute kidney injury

1 paper1 finding

Humans1

Interventions

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NAD+ + PF-543

downin mice1

1 study

NAD+ + PF-543 decreases sepsis-associated acute kidney injury in mice.
“Combining NAD+ and PF-543 synergistically attenuated SA-AKI.”
Animalscecal ligation and puncture-induced sepsis-associated acute kidney injurykidney
H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury
Theranostics18 Feb 2026

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Theranostics18 Feb

H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury

Study in peoplePyroptosis

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IER3 drives the transition from sepsis-associated AKI to CKD by suppressing the mitochondrial translocation of PRDX5

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