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Chrysin

Intervention

3 papers6 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: Innovation and Entrepreneurship Talent Project of Lanzhou and 3 more
  • Model organisms2

Outcomes

5

Lifespan

upin worms2

2 studies

  1. Chrysin extends lifespan in worms.

    “We identified chrysin and apigenin, which reduced ATP production and increased the lifespan of worms.”

    Model organisms

    Transient inhibition of mitochondrial function by chrysin and apigenin prolong longevity via mitohormesis in C. elegans

    Free radical biology & medicineApr 5, 2023

  2. Chrysin extends lifespan in worms.

    “expanded the nematodes' lifespan”

    Model organismstransgenic C. elegans models of PD

    Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease

    ACS chemical neuroscienceFeb 4, 2022

Oxidative stress and ROS signaling

downin worms1

1 study

  1. Chrysin decreases oxidative stress and ROS signaling in worms.

    “reducing the internal cellular reactive oxygen species levels in 6-OHDA-intoxicated C. elegans”

    Model organisms6-OHDA-intoxicated

    Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease

    ACS chemical neuroscienceFeb 4, 2022

More on Oxidative stress and ROS signaling

Food-sensing behavioral disability

downin worms1

1 study

  1. Chrysin decreases food-sensing behavioral disability in worms.

    “reduced food-sensing behavioral disabilities”

    Model organismstransgenic C. elegans models of PD

    Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease

    ACS chemical neuroscienceFeb 4, 2022

Neurodegeneration

downin worms1

1 study

  1. Chrysin decreases neurodegeneration in worms.

    “diminished DA neuron degeneration induced by 6-hydroxydopamine (6-OHDA)”

    Model organisms6-hydroxydopamine-induced

    Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease

    ACS chemical neuroscienceFeb 4, 2022

α-synuclein aggregation

downin worms1

1 study

  1. Chrysin decreases α-synuclein aggregation in worms.

    “chrysin reduced the aggregative toxicity of α-Syn”

    Model organismstransgenic C. elegans models of Parkinson's disease

    Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease

    ACS chemical neuroscienceFeb 4, 2022

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