Carcinogen

Exposure

2 papers1 finding

  • 1 lab in 1 country
  • Funders: Japan Agency for Medical Research and Development and 3 more
  • Animals1
  • Cells1

Outcomes

1

Cellular senescence

downin mice1

1 study
  1. Carcinogen inhibits cellular senescence in mice.

    “carcinogens can suppress McSC seno-differentiation, even in cells harbouring double-strand breaks, by activating arachidonic acid metabolism and the niche-derived KIT ligand, thereby promoting McSC self-renewal.”

    Animalsin cells harbouring double-strand breaks

    Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma

    Nature cell biology6 Oct 2025

More on Cellular senescence

Funding

1 grant since 2022

National Cancer InstituteUS$2m

Latest

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bioRxiv

DNA-based model detects age-linked shifts in cells

In sorted cell populations, a machine-learning model found age-associated shifts in DNA marks towards a developmental family that includes connective-tissue cells.In sorted cell populations, a machine-learning model found age-associated shifts in DNA marks towards a developmental family that includes connective-tissue cells.

Preprint: experiments in cellsBiomarkers