Cancer treatment
4 papers study it9 findings
Across all fields, 4 papers: 2 observational studies in people, 2 reviews
- 3 independent labs in 2 countries
- Funders: FOD Volksgezondheid, Veiligheid van de Voedselketen en Leefmilieu and 4 more
- Humans2
Outcomes
4Cellular senescence
upin humans1upin reviews1
2 studies
Cellular senescence
upin humans1upin reviews1
Cancer treatment induces cellular senescence in humans.
“Treatment modalities for cancer can induce EC senescence, leading to the development of SAS phenotype and subsequent atherosclerosis in cancer survivors.”
Reviewin cancer survivors
Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors
Frontiers in cardiovascular medicine
Cancer treatment induces cellular senescence.
“cancer treatments induce cellular senescence in tumor cells and in normal, nontumor tissue, thereby helping mediate the onset of several chronic diseases.”
Review
The Achilles' heel of cancer survivors: fundamentals of accelerated cellular senescence
The Journal of clinical investigation
Reproductive lifespan
downin humans1
1 study
Reproductive lifespan
downin humans1
Cancer treatment shortens reproductive lifespan in humans.
“individuals receiving treatment for cancer which subsequently shortens their reproductive lifespan”
Reviewcancer treatment
Journal of clinical medicine
Instrumental activities of daily living
downin humans1−41%
1 study
Instrumental activities of daily living
downin humans1−41%
Cancer treatment decreases instrumental activities of daily living in humans (41.0%).
“Functional decline in IADL was observed in 41.0% of patients.”
Humansolder patients with cancer and a frailty risk profileapproximately three monthsn = 3,388
Journal of geriatric oncology
Activities of daily living
downin humans1−24%
1 study
Activities of daily living
downin humans1−24%
Cancer treatment decreases activities of daily living in humans (23.6%).
“Functional decline was observed in 23.6% of patients.”
Humansolder patients with cancer and a frailty risk profileapproximately three monthsn = 3,388
Journal of geriatric oncology
Associations
3Chronic kidney disease
upin humans2+14% paf
2 studies
Chronic kidney disease
upin humans2+14% paf
Cancer treatment raises the risk of chronic kidney disease in humans (14.1% PAF).
“Cancer treatment contributed to 11% of heart and pulmonary conditions and 14.1% of chronic kidney disease.”
HumansB-NHL survivors
Cancer causes & control : CCC
Cancer treatment raises the risk of chronic kidney disease in humans (14.1% PAF).
“Cancer treatment contributed to 11% of heart and pulmonary conditions and 14.1% of chronic kidney disease.”
HumansB-cell non-Hodgkin's lymphoma survivors
Research SquarePreprint
Atherosclerotic cardiovascular disease
upin humans1
1 study
Atherosclerotic cardiovascular disease
upin humans1
Cancer treatment raises the risk of atherosclerotic cardiovascular disease in humans.
“Cancer survivors undergone treatment face an increased risk of developing atherosclerotic cardiovascular disease (CVD)”
Reviewin cancer survivors
Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors
Frontiers in cardiovascular medicine
Telomere length
mixedin humans1
1 study
Telomere length
mixedin humans1
Cancer treatment is associated with telomere length in humans (Three studies reported significant shortening; two reported elongation).
“Among the hematological cancer studies, three showed statistically significant decreases in telomere length with treatment, and two showed elongation.”
Reviewhematological cancer
The Effect of Cancer Treatments on Telomere Length: A Systematic Review of the Literature
Journal of the National Cancer Institute
Funding
1 grant since 2019National Institute on AgingUS$232k