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Metformin + caffeic acid

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 1 more
  • Cells1

Outcomes

2

Cellular senescence

downin human cells1

1 study

  1. Metformin + caffeic acid decreases cellular senescence in human cells.

    “Metformin and caffeic acid also restore cellular proliferation and reduce SA-β-gal activity during senescence induction.”

    Cellsduring senescence induction in MRC-5 cells

    Addition of Polyphenols to Drugs: The Potential of Controlling "Inflammaging" and Fibrosis in Human Senescent Lung Fibroblasts In Vitro

    International journal of molecular sciencesJun 28, 2024

More on Cellular senescence

Senescence-associated secretory phenotype (SASP)

downin human cells1

1 study

  1. Metformin + caffeic acid inhibits senescence-associated secretory phenotype (SASP) in human cells.

    “The combination that demonstrated the best results was metformin and caffeic acid, by inhibiting IL-6 and IL-8 in senescent MRC-5 cells.”

    Cellsin senescent MRC-5 cells

    Addition of Polyphenols to Drugs: The Potential of Controlling "Inflammaging" and Fibrosis in Human Senescent Lung Fibroblasts In Vitro

    International journal of molecular sciencesJun 28, 2024

More on Senescence-associated secretory phenotype (SASP)

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