Botulinum toxin

Intervention

3 papers3 findings

  • 1 lab in 1 country
  • Funders: Department of Science and Technology, Ministry of Science and Technology, India and 4 more
  • Animals1

Outcomes

3

Ptgs2 mRNA expression

downin mice1

1 study
  1. Botulinum toxin decreases Ptgs2 mRNA expression in mice.

    “Additionally, the reduced number of microglia accompanied by decreased mRNA expression of COX-2 was evident in the BoNT-treated animals.”

    Animalshippocampus

    The proneurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice

    bioRxiv (Cold Spring Harbor Laboratory)16 Jun 2024Preprint

More on Ptgs2 mRNA expression

Microglial count

downin mice1

1 study
  1. Botulinum toxin decreases microglial count in mice.

    “Additionally, the reduced number of microglia accompanied by decreased mRNA expression of COX-2 was evident in the BoNT-treated animals.”

    Animalshippocampus

    The proneurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice

    bioRxiv (Cold Spring Harbor Laboratory)16 Jun 2024Preprint

More on Microglial count

DCX-positive immature neuron count

upin mice1

1 study
  1. Botulinum toxin increases DCX-positive immature neuron count in mice.

    “Results revealed a prominent increase in DCX-positive cells in the BoNT-treated animals compared to the control group.”

    Animalscompared with the control grouphippocampus

    The proneurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice

    bioRxiv (Cold Spring Harbor Laboratory)16 Jun 2024Preprint

More on DCX-positive immature neuron count

Funding

1 grant since 2020

American Heart AssociationUS$131.4k

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