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Biglycan

Intervention

1 paper4 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Korea Centers for Disease Control and Prevention and 2 more
  • Humans1

Outcomes

4

Lipid accumulation

downin cells1

1 study

  1. Biglycan decreases lipid accumulation in cells.

    “BGN attenuated senescence-induced lipid accumulation and ROS generation.”

    Cellssenescence in hepatocytes

    Biglycan Alleviates Age-Related Muscle Atrophy and Hepatocellular Senescence

    International journal of molecular sciences26 Aug 2025

Reactive oxygen species

downin cells1

1 study

  1. Biglycan decreases reactive oxygen species in cells.

    “BGN attenuated senescence-induced lipid accumulation and ROS generation.”

    Cellssenescence in hepatocytes

    Biglycan Alleviates Age-Related Muscle Atrophy and Hepatocellular Senescence

    International journal of molecular sciences26 Aug 2025

More on Reactive oxygen species

P21

downin cells1

1 study

  1. Biglycan decreases P21 in cells.

    “BGN decreased the expression of the senescence marker p21 and senescence-associated secretory phenotype (SASP)-related genes in hepatocytes.”

    Cellshepatocytes

    Biglycan Alleviates Age-Related Muscle Atrophy and Hepatocellular Senescence

    International journal of molecular sciences26 Aug 2025

More on P21

Muscle mass loss

downin mice1

1 study

  1. Biglycan decreases muscle mass loss in mice.

    “BGN counteracted the expression of atrophy-related genes involved in muscle degradation and mitigated muscle mass loss by regulating AKT/mTOR signaling pathway.”

    Animals

    Biglycan Alleviates Age-Related Muscle Atrophy and Hepatocellular Senescence

    International journal of molecular sciences26 Aug 2025

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