Ampicillin + vancomycin + neomycin + metronidazole

1 paper4 findings

PubChem 6249 PubChem 14969 PubChem 8378 PubChem 4173 ChEBI 28971 ChEBI 28001 ChEBI 7508 ChEBI 6909

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

IL-10

downin rats1

1 study

Ampicillin + vancomycin + neomycin + metronidazole decreases IL-10 in rats.
“Inflammatory profiling revealed that IL-10 decreased in both tissues, whereas TNF-α and IL-1β remained unchanged.”
Animalsin aged male ratsliver and white adipose tissueone-weekmales
Antibiotic exposure alters the LEAP-2/ghrelin axis and anti-inflammatory tone in aged male rat liver and adipose tissue
Biogerontology12 Dec 2025

Latest

1 in 12 months

Biogerontology12 Dec

Antibiotic exposure alters the LEAP-2/ghrelin axis and anti-inflammatory tone in aged male rat liver and adipose tissue

Experiments in ratsInflammation

Paper

Journal of Molecular Neuroscience10 Sep

Ketogenic Diet Mitigates Age-Related Cognitive Decline and Neuroinflammation in Rats, While Antibiotics Exacerbate Brain Health Risks

Experiments in 32 ratsKetogenic diet

Paper