Allantoin
Allantoin has been studied in 4 papers since 2015: none in people yet, 3 in animals. The research so far is in animals. The newest paper, Jul 1, 2021: “Allantoin may modulate aging impairments, symptoms and cancers”.
See all 16 papers on allantoin
At a glance
The findings reach mice, none yet in people; independent labs found the same change in worms or flies. 3 independent labs in 3 countries.
None of its findings points the other way.
- 3 independent labs in 3 countries
- Funders: National Institutes of Health and 7 more
- Animals1
- Model organisms2
- In silico1
What did lifespan studies of allantoin find?
DrugAgeDrugAge records 3 results from 2 papers: 2 in C. elegans and 1 in D. melanogaster. Average lifespan is the mean or the median, as each paper reports it.
What did studies of allantoin find?
4Studies of allantoin measured 4 outcomes, among them collagenase activity, lipid and ceramide metabolism and oxidative stress and ROS signaling.
Collagenase activity
downin rats1
1 study
Collagenase activity
downin rats1
Allantoin inhibits collagenase activity in rats.
“Allantoin improves aging process indicated by its collagenase inhibitory effect.”
Animalsinjected i.p.100 mg/kgmales
Allantoin may modulate aging impairments, symptoms and cancers
Pakistan journal of pharmaceutical sciences
Lipid and ceramide metabolism
upin rats1
1 study
Lipid and ceramide metabolism
upin rats1
Allantoin increases lipid and ceramide metabolism in rats.
“Allantoin showed an increase in lipogenesis was recorded as a hepatic energy targeting muscles.”
Animalsinjected i.p.liver100 mg/kgmales
Allantoin may modulate aging impairments, symptoms and cancers
Pakistan journal of pharmaceutical sciences
Oxidative stress and ROS signaling
downin rats1
1 study
Oxidative stress and ROS signaling
downin rats1
Allantoin decreases oxidative stress and ROS signaling in rats.
“Allantoin showed improvement in all in vivo studied oxidative stress parameters.”
Animalsinjected i.p.100 mg/kgmales
Allantoin may modulate aging impairments, symptoms and cancers
Pakistan journal of pharmaceutical sciences
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Allantoin extends lifespan in worms (wild-type worms).
“An increase in lifespan and healthspan was observed for all drugs except geldanamycin when fed to wild-type worms”
Model organismswild-type worms
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans
Aging cell
What is allantoin linked with?
1Studies link allantoin with Metformin gene signature.
Metformin gene signature
upin silico1
1 study
Metformin gene signature
upin silico1
Allantoin is associated with metformin gene signature in silico (LINCS signature matching, computational screen).
“including allantoin and ginsenoside (metformin)”
In silicoLINCS signature matching, computational screenn = 800
Towards natural mimetics of metformin and rapamycin
Aging