Akt inhibitor

1 paper

In silico1

Latest

4 in 12 months

bioRxiv26 Jun

A Generalised Epigenetic Clock Reveals Therapeutic Vulnerabilities Linked to Ageing in Cancer Cells

Preprint: computational studyEpigenetic clock

Cell Death & Disease17 Jun

Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P₂-dependent macropinocytic dysregulation in cancer cells

Experiments in miceCancer

Archives of Oral Biology8 Dec

Inhibition of protein kinase C activity enables mineralization of senescent dental follicle cells with almost no osteogenic differentiation potential

Experiments in human cellsCellular senescence

Acta Neuropathologica Communications2 Dec

Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain

Experiments in miceCellular homeostasis

Journal of Cachexia, Sarcopenia and Muscle15 Apr

HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice

Experiments in miceMuscle atrophy

Frontiers in Bioscience28 Mar

The Protective Effects of Ecdysterone on Cognitive Impairment through Regulating Akt/GSK-3β/Nrf2 Signaling Pathway and Oxidative Stress in Cognitive Mice Model and Aβ-Induced Cell Neurotoxicity

Experiments in miceCognitive impairment

Genes & Diseases11 Sep

Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

Study in peopleMechanisms

Biochemical Pharmacology19 Jun

Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells

Experiments in animalsInterventions

Experimental Gerontology20 Jan

Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence

Experiments in cellsInterventions

Cells28 Oct

Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens

Experiments in cellsInterventions