AGN194310

1 paper2 findings

1 lab in 1 country

Funder: KWF Kankerbestrijding

Animals1

Outcomes

2

Physical function

upin mice1

1 study

AGN194310 improves physical function in mice.
“In aged mice, abemaciclib and agn194310 reduced systemic NASP expression and improved physical performance.”
Animals
Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
Nature aging17 Jul 2026

NF-κB-associated SASP

downin mice1

1 study

AGN194310 decreases NF-κB-associated SASP in mice.
“In aged mice, abemaciclib and agn194310 reduced systemic NASP expression and improved physical performance.”
Animals
Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
Nature aging17 Jul 2026

More on NF-κB-associated SASP

Latest

1 in 12 months

Nature Aging18 Jul

Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy

Experiments in miceInterventions