Caloric restriction + aerobic exercise

1. Caloric restriction + aerobic exercise increases cross-sectional area in rats.

   “An 8-week DR + ET intervention effectively increased the cross-sectional area and protein content of the soleus muscle.”

   Animalsin HFD-induced obese ratssoleus muscle8-weekmales

   Dietary restriction and aerobic exercise alleviate obesity-related skeletal muscle impairment via the miR-130/PPARγ axis and IGF-1/Akt/mTOR signaling activation

   Scientific reports·Apr 1, 2026

1. Caloric restriction + aerobic exercise increases progesterone in humans (p < 0.05).

   “along with significantly higher serum progesterone levels (p < 0.05)”

   Human trialin obese females with PMS receiving Brufen12 weeksfemalesn = 40

   Effect of Caloric Restriction and Aerobic Exercise on Premenstrual Syndrome, Anthropometric, and Hormonal Parameters in Obese Females: A Randomized Controlled Trial

   Physiotherapy research international : the journal for researchers and clinicians in physical therapy·Dec 13, 2024

More on Progesterone

1. Caloric restriction + aerobic exercise decreases cortisol in humans (p < 0.05).

   “reductions in PMSS scores, weight, BMI, waist and hip circumferences, W/H ratio, and serum cortisol”

   Human trialin obese females with PMS receiving Brufen12 weeksfemalesn = 40

   Effect of Caloric Restriction and Aerobic Exercise on Premenstrual Syndrome, Anthropometric, and Hormonal Parameters in Obese Females: A Randomized Controlled Trial

   Physiotherapy research international : the journal for researchers and clinicians in physical therapy·Dec 13, 2024

More on Cortisol

1. Caloric restriction + aerobic exercise decreases body weight in humans (p < 0.05).

   “Post-treatment, the study group (B) demonstrated significantly greater improvements compared to the control group (A), including reductions in PMSS scores, weight, BMI”

   Human trialin obese females with PMS receiving Brufen12 weeksfemalesn = 40

   Effect of Caloric Restriction and Aerobic Exercise on Premenstrual Syndrome, Anthropometric, and Hormonal Parameters in Obese Females: A Randomized Controlled Trial

   Physiotherapy research international : the journal for researchers and clinicians in physical therapy·Dec 13, 2024

1. Caloric restriction + aerobic exercise improves premenstrual syndrome scale in humans (p < 0.05).

   “Post-treatment, the study group (B) demonstrated significantly greater improvements compared to the control group (A), including reductions in PMSS scores”

   Human trialin obese females with PMS receiving Brufen12 weeksfemalesn = 40

   Effect of Caloric Restriction and Aerobic Exercise on Premenstrual Syndrome, Anthropometric, and Hormonal Parameters in Obese Females: A Randomized Controlled Trial

   Physiotherapy research international : the journal for researchers and clinicians in physical therapy·Dec 13, 2024

More on Premenstrual syndrome scale