Advanced paternal age

1. Advanced paternal age impairs semen quality in humans.

   “Advanced paternal age is associated with progressive alterations in semen volume, sperm motility, morphology, vitality, and biofunctional parameters”

   Review

   Advancing paternal age: Effects on sperm quality and offspring health

   Maturitas·1 Jul 2026

1. Advanced paternal age impairs progeny stakes race winning in E. caballus (OR 3.58, 95% CI 2.43-5.29).

   “win a stakes race (OR = 3.58, 95% CI 2.43-5.29) than those conceived at ≥ 19 years.”

   Animals

   Advanced paternal age is associated with reduced reproductive success and offspring racing performance in Australian Thoroughbred racehorses

   Scientific reports·23 Jun 2026

1. Advanced paternal age impairs progeny stakes race placing in E. caballus (OR 3.71, 95% CI 2.74-5.04).

   “place in a stakes race (OR = 3.71, 95% CI 2.74-5.04)”

   Animals

   Advanced paternal age is associated with reduced reproductive success and offspring racing performance in Australian Thoroughbred racehorses

   Scientific reports·23 Jun 2026

1. Advanced paternal age impairs likelihood of progeny racing in E. caballus (OR 2.21, 95% CI 1.93-2.52).

   “Progeny conceived when stallions were ≤ 8 years were more likely to race (odds ratio [OR] = 2.21, 95% CI 1.93-2.52)”

   Animals

   Advanced paternal age is associated with reduced reproductive success and offspring racing performance in Australian Thoroughbred racehorses

   Scientific reports·23 Jun 2026

1. Advanced paternal age has no effect on FGFR3 c.1948A>G mutant sperm in humans.

   “exhibited reduced transmission into sperm and no significant age-related increase”

   Humansspermmales

   Exploring the Micro-Mosaic Landscape of FGFR3 Mutations in the Ageing Male Germline and Their Potential Implications in Meiotic Differentiation

   Genes·30 Jan 2024

More on FGFR3 c.1948A>G mutant sperm

1. Advanced paternal age increases mutant sperm production in humans.

   “a significant increase in mutant sperm with the donor's age”

   Humansspermmales

   Exploring the Micro-Mosaic Landscape of FGFR3 Mutations in the Ageing Male Germline and Their Potential Implications in Meiotic Differentiation

   Genes·30 Jan 2024

1. Advanced paternal age decreases telomere length in mice.

   “The mt-cn and TL of AF-derived blastocysts were lower and shorter, respectively, than those of YF-derived blastocysts.”

   Animalscompared to young fathers (13-23 weeks old)blastocyst

   Effect of paternal aging and vitrification on mitochondrial DNA copy number and telomere length of mouse blastocysts

   The Journal of reproduction and development·25 Jan 2024

More on Telomere length

1. Advanced paternal age decreases mitochondrial DNA copy number in mice.

   “The mt-cn and TL of AF-derived blastocysts were lower and shorter, respectively, than those of YF-derived blastocysts.”

   Animalscompared to young fathers (13-23 weeks old)blastocyst

   Effect of paternal aging and vitrification on mitochondrial DNA copy number and telomere length of mouse blastocysts

   The Journal of reproduction and development·25 Jan 2024

More on Mitochondrial DNA copy number

1. Advanced paternal age activates mTOR signalling in mice.

   “Gene expression analyses, biochemical experiments, and functional studies revealed evidence for an overactive mTORC1 signaling pathway in old father offspring mice.”

   Animalsin old father offspring mice

   Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

   Proceedings of the National Academy of Sciences of the United States of America·21 Feb 2018

More on mTOR signalling

1. Advanced paternal age shortens lifespan in mice.

   “old father offspring mice showed a reduced life span and an exacerbated development of aging traits compared with young father offspring mice.”

   Animalscompared with young father offspring mice

   Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

   Proceedings of the National Academy of Sciences of the United States of America·21 Feb 2018

1. Advanced paternal age raises the risk of neuropsychiatric disorder in humans.

   “paternal aging contributes to a higher risk of neuropsychiatric and metabolic disorders in the offspring”

   Review

   Advancing paternal age: Effects on sperm quality and offspring health

   Maturitas·1 Jul 2026

More on Neuropsychiatric disorder

1. Advanced paternal age raises the risk of miscarriage in humans.

   “Advanced paternal age independently contributes to miscarriage, preterm birth and offspring neurodevelopmental risks via epigenetic alterations and de novo mutations.”

   Reviewadvanced paternal agemales

   Delayed childbearing and reproductive ageing: a narrative review

   Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·9 Jun 2026

1. Advanced paternal age is associated with gene expression in human cells.

   “Significant enrichment of neurodevelopmental signaling pathways was also observed for differentially expressed genes, but only in the ICM.”

   CellsAPA-derived blastocysts compared to those from young fathersinner cell massmales

   Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation

   Human genomics·26 Mar 2024

1. Advanced paternal age is associated with DNA methylation in human cells.

   “Significant differential methylation and transcription was observed concurrently in ICM and TE lineages of APA-derived blastocysts compared to those from young fathers.”

   CellsAPA-derived blastocysts compared to those from young fathersinner cell mass and trophectodermmales

   Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation

   Human genomics·26 Mar 2024

More on DNA methylation