Rapamycin + acarbose + phenylbutyrate

1. Rapamycin + acarbose + phenylbutyrate activates autophagy in mice.

   “the drug cocktail was able to increase resilience to cognitive impairment, inflammation, and AD protein aggregation while enhancing autophagy and synaptic integrity, preferentially in female cohorts.”

   Animalsin an adeno-associated-viral vector model of early-stage ADfemales

   A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice

   bioRxiv : the preprint server for biology·30 Jan 2024Preprint

2. Rapamycin + acarbose + phenylbutyrate increases autophagy in mice.

   “autophagy was increased in the brains of mice given the drug cocktail.”

   Animalsbrain

   A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways

   bioRxiv (Cold Spring Harbor Laboratory)·9 Sep 2022Preprint

More on Autophagy

1. Rapamycin + acarbose + phenylbutyrate decreases inflammation in mice.

   “the drug cocktail was able to increase resilience to cognitive impairment, inflammation, and AD protein aggregation while enhancing autophagy and synaptic integrity, preferentially in female cohorts.”

   Animalsin an adeno-associated-viral vector model of early-stage ADfemales

   A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice

   bioRxiv : the preprint server for biology·30 Jan 2024Preprint

More on Inflammation

1. Rapamycin + acarbose + phenylbutyrate improves cognitive impairment in mice.

   “the drug cocktail was able to increase resilience to cognitive impairment, inflammation, and AD protein aggregation while enhancing autophagy and synaptic integrity, preferentially in female cohorts.”

   Animalsin an adeno-associated-viral vector model of early-stage ADfemales

   A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice

   bioRxiv : the preprint server for biology·30 Jan 2024Preprint

1. Rapamycin + acarbose + phenylbutyrate decreases cognitive impairment in mice.

   “treatment with the drug cocktail was overall more effective than any of the individual drugs for relieving cognitive impairment by targeting multiple aging pathways.”

   Animalscompared with individual drugs; inferred from molecular endpoint assessments

   A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways

   bioRxiv (Cold Spring Harbor Laboratory)·9 Sep 2022Preprint

More on Cognitive impairment

1. Rapamycin + acarbose + phenylbutyrate decreases age-related lesions in mice.

   “The severity of age-related lesions in heart, lungs, liver, and kidney was consistently decreased in mice treated with the cocktail compared to mice treated with individual drugs or control”

   Animalscocktail diet vs individual drugs or control14 ppm rapamycin, 1000 ppm acarbose, 1000 ppm phenylbutyrate3 months

   Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

   Scientific reports·4 May 2022

1. Rapamycin + acarbose + phenylbutyrate improves strength in mice.

   “increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control”

   Animalscocktail diet vs individual drugs or control14 ppm rapamycin, 1000 ppm acarbose, 1000 ppm phenylbutyrate3 months

   Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

   Scientific reports·4 May 2022

1. Rapamycin + acarbose + phenylbutyrate improves cognitive function in mice.

   “improved cognition, increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control”

   Animalscocktail diet vs individual drugs or control14 ppm rapamycin, 1000 ppm acarbose, 1000 ppm phenylbutyrate3 months

   Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

   Scientific reports·4 May 2022

1. Rapamycin + acarbose + phenylbutyrate decreases body fat in mice.

   “Mice treated with the cocktail showed a sex and strain-dependent phenotype consistent with healthy aging including decreased body fat”

   Animalscocktail diet vs individual drugs or control14 ppm rapamycin, 1000 ppm acarbose, 1000 ppm phenylbutyrate3 months

   Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

   Scientific reports·4 May 2022