AAV9-SHRNA-MEDIATED OXR1 silencing

InterventionPreclinical

1 paper1 finding

  • 1 lab in 1 country
  • Funders: Australian Research Council and 3 more
  • Animals1

Outcomes

1

Bone loss

downin mice1

1 study
  1. AAV9-SHRNA-MEDIATED OXR1 silencing decreases bone loss in mice.

    “intraosseous AAV9-shRNA-mediated Oxr1 silencing or pharmacological OXR1 inhibition suppresses osteoclast activity and attenuates bone loss.”

    Animalsovariectomy-induced osteoporosisAAV9-shRNAbone

    Targeting a cell regulator reduced bone loss in mice

    Nature communications5 Sep 2026

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Nature Communications

Targeting a cell regulator reduced bone loss in mice

In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.

Experiments in miceBones and joints