TPR
5 papers5 findings
- 3 independent labs in 1 country
- Funders: Agence Nationale de la Recherche and others
- Animals1
- Cells4
Effects
4Senescence-associated heterochromatin foci formation and maintenance
is required forin cells1is required forin mammals cells1
2 studies
Senescence-associated heterochromatin foci formation and maintenance
is required forin cells1is required forin mammals cells1
TPR is required for senescence-associated heterochromatin foci formation and maintenance in mammals cells.
“In particular, the nucleoporin TPR is necessary for both formation and maintenance of SAHFs.”
Cellsduring oncogene-induced senescence
Nuclear pore density controls heterochromatin reorganization during senescence
Genes & developmentJan 28, 2019
TPR is required for senescence-associated heterochromatin foci formation and maintenance in cells.
“the nucleoporin TPR is required for both SAHF formation and maintenance.”
Cellsoncogene-induced senescence
Nuclear pore density controls heterochromatin reorganization during senescence
bioRxiv (Cold Spring Harbor Laboratory)Jul 21, 2018Preprint
Cytoplasmic chromatin fragments
is required forin human cells1
1 study
Cytoplasmic chromatin fragments
is required forin human cells1
TPR is required for cytoplasmic chromatin fragments in human cells.
“we link this to the formation of heterochromatin-enriched cytoplasmic chromatin fragments thought to bleb off from the nuclear periphery”
Cellsduring senescence
TPR is required for cytoplasmic chromatin fragment formation during senescence
eLifeDec 3, 2024
Immune response
is required forin human cells1
1 study
Immune response
is required forin human cells1
TPR is required for immune response in human cells.
“TPR is required for the activation of innate immune signalling at these early stages of senescence”
Cellsduring early stages of senescence
TPR is required for cytoplasmic chromatin fragment formation during senescence
eLifeDec 3, 2024
NF-κB signalling
is required forin human cells1
1 study
NF-κB signalling
is required forin human cells1
TPR is required for NF-κB signalling in human cells.
“TPR, a protein of the nuclear pore complex basket required for heterochromatin re-organisation during senescence, is also required for the very early activation of NF-κB signalling”
Cellsduring oncogene-induced senescence
TPR is required for cytoplasmic chromatin fragment formation during senescence
eLifeDec 3, 2024