TOP2A
- 2 independent labs in 1 country
- 13 trials, 7 with no results posted
- Funder: Natural Science Foundation of Jiangxi Province
- 12 of 13 trials sponsored by developers of drugs on it
- Humans1
- Animals2
Interventions
1Naringenin
upin cells1
1 study
Naringenin
upin cells1
Naringenin increases TOP2A in cells.
“Mechanistically, naringenin was associated with suppression of p53 signaling, relief of p53-mediated transcriptional repression of TOP2A, and restoration of TOP2A expression.”
Cellsduring naringenin treatment
Frontiers in pharmacology8 May 2026
Effects
2Cell survival
upin mouse cells1
1 study
Cell survival
upin mouse cells1
TOP2A increases cell survival in mouse cells.
“Overexpression enhanced cell survival, reduced apoptosis, and maintained mitochondrial membrane potential (MMP)”
Cellsoverexpression
PBX3 regulates mast cell parthanatos via TOP2A mediated DNA damage in allergic rhinitis
iScience20 Mar 2026
Apoptosis
downin mouse cells1
1 study
Apoptosis
downin mouse cells1
TOP2A decreases apoptosis in mouse cells.
“Overexpression enhanced cell survival, reduced apoptosis, and maintained mitochondrial membrane potential (MMP)”
Cellsoverexpression
PBX3 regulates mast cell parthanatos via TOP2A mediated DNA damage in allergic rhinitis
iScience20 Mar 2026
Upstream
1PBX3
upin mouse cells1
1 study
PBX3
upin mouse cells1
PBX3 increases TOP2A in mouse cells.
“PBX3 directly binds to the TOP2A promoter to regulate transcription”
Cellsin vitro
PBX3 regulates mast cell parthanatos via TOP2A mediated DNA damage in allergic rhinitis
iScience20 Mar 2026
Latest
3 in 12 monthsFrontiers in Pharmacology
Naringenin inhibited vascular calcification and attenuated senescence-associated changes through the p53/TOP2Aaxis
Study in peopleVascular calcification
Calcified Tissue International
Integrated Bioinformatics Analysis and Experimental Validation of the Role of Cellular Senescence in Osteoporosis
Experiments in miceCellular senescence