TMBIM1

1. TMBIM1 inhibits TGF-β signalling in rats.

   “the TGF-β signaling pathway was blocked by the lysosomal degradation of TGF-β type I receptors (TGFBR1)”

   AnimalsTMBIM1 regulation

   Transmembrane BAX inhibitor motif containing 1 inhibition of lysosomal degradation of TGF-β receptor 1 suppresses cellular senescence and hepatocarcinogenesis

   The Journal of biological chemistry·4 Nov 2025

More on TGF-β signalling

1. TMBIM1 inhibits cellular senescence in rats.

   “Furthermore, Tmbim1 downregulated the expression of Cdkn2a, Cdkn1a and SASP mRNA to inhibit CS.”

   Animalsoverexpression

   Transmembrane BAX inhibitor motif containing 1 inhibition of lysosomal degradation of TGF-β receptor 1 suppresses cellular senescence and hepatocarcinogenesis

   The Journal of biological chemistry·4 Nov 2025

More on Cellular senescence

1. TMBIM1 extends lifespan in rats.

   “the occurrence of hepatocellular carcinoma (HCC) was highly inhibited and overall survival was prolonged.”

   AnimalsTmbim1-overexpressed rat model

   Transmembrane BAX inhibitor motif containing 1 inhibition of lysosomal degradation of TGF-β receptor 1 suppresses cellular senescence and hepatocarcinogenesis

   The Journal of biological chemistry·4 Nov 2025

1. TMBIM1 protects against hepatocellular carcinoma in rats.

   “In a Tmbim1-overexpressed rat model, the occurrence of hepatocellular carcinoma (HCC) was highly inhibited and overall survival was prolonged.”

   AnimalsTmbim1-overexpressed rat model

   Transmembrane BAX inhibitor motif containing 1 inhibition of lysosomal degradation of TGF-β receptor 1 suppresses cellular senescence and hepatocarcinogenesis

   The Journal of biological chemistry·4 Nov 2025

More on Hepatocellular carcinoma