RS1990622-A
2 papers study it5 findings
- 1 lab in 1 country
- Funders: Australian Government and 4 more
- Humans2
Effects
2Sulfatides
downin humans1
1 study
Sulfatides
downin humans1
RS1990622-A decreases sulfatides in humans.
“levels of myelin-enriched sulfatides and hexosylceramides were significantly lower, and polyunsaturated phospholipids were higher, in rs1990622-A carriers”
HumansCA1 hippocampusn = 74
Research squarePreprint
TMEM106B
upin humans1
1 study
TMEM106B
upin humans1
RS1990622-A increases TMEM106B in humans (greatest effect size).
“The increase in TMEM106B levels with age was specific to carriers of the rs1990622-A allele in the TMEM106B gene”
Humanscarriers of the rs1990622-A alleleCA1 hippocampusn = 74
Research squarePreprint
Associations
3Sulfatides
downin humans1
1 study
Sulfatides
downin humans1
RS1990622-A is associated with sulfatides in humans.
“levels of myelin-enriched sulfatides and hexosylceramides were significantly lower, and polyunsaturated phospholipids were higher, in rs1990622-A carriers”
Humansneurologically normal human donors, after controlling for APOE genotypeCA1 hippocampusn = 74
Molecular neurodegeneration
TMEM106B fibrils
upin humans1
1 study
TMEM106B fibrils
upin humans1
RS1990622-A is associated with TMEM106B fibrils in humans.
“Rs1990622-A was also associated with higher TMEM106B fibril content.”
Humansneurologically-normal human donorsCA1 hippocampusn = 74
Molecular neurodegeneration
TMEM106B
upin humans1
1 study
TMEM106B
upin humans1
RS1990622-A is associated with TMEM106B in humans.
“The increase in TMEM106B levels with ageing was specific to carriers of the rs1990622-A allele in the TMEM106B gene”
Humansneurologically-normal human donors, controlling for APOE genotype, age, gender, PMICA1 hippocampusn = 74
Molecular neurodegeneration