TMEM106B
4 papers study it31 more mention it1 finding
- Humans4
Associations
1RS1990622-A
upin humans1
1 study
RS1990622-A
upin humans1
RS1990622-A is associated with TMEM106B in humans.
“The increase in TMEM106B levels with ageing was specific to carriers of the rs1990622-A allele in the TMEM106B gene”
Humansneurologically-normal human donors, controlling for APOE genotype, age, gender, PMICA1 hippocampusn = 74
Molecular neurodegeneration
Funding
2 grants since 2018National Institute of Neurological Disorders and StrokeUS$3.1m
Latest
9 papers in 12 monthsmedRxiv
TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain
Preprint: cohort study of 1,299 peopleMechanisms
Life Sciences
Plasma proteomics reveal key proteins mediating vascular aging
Mendelian randomization in peopleMechanisms
Journal of Neuropathology and Experimental Neurology
GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions
Genetic association study of 8,121 peopleMechanisms
Brain Pathology
Associations between TMEM106B C-terminal fragment aggregation, age, and TDP-43 or tau pathology
Cross-sectional study in peopleMechanisms
Experimental Gerontology
Discovery of frailty-linked proteins through multi-omics integration of brain and plasma proteomes with GWAS datasets
Mendelian randomization in 386,565 peopleMechanisms
AAIC 2025 Abstract
Investigating the Effect of Increased TMEM106B in a Tauopathy Model
Experiments in fliesMechanisms
AAIC 2025 Abstract
Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration
Case-control study of 5,792 peopleMechanisms
Research Square
Distributional genetic effects reveal context-dependent molecular regulation in human brain aging and Alzheimer's disease
Preprint: computational studyHuman genetics
medRxiv
Long-read genome sequencing and multi-omics in aging and neurodegeneration
Preprint: cohort study of 551 peopleMechanisms