TMEM106B fibrils

1 paper studies it2 more mention it1 finding

Humans1

Associations

1

RS1990622-A

upin humans1

1 study

RS1990622-A is associated with TMEM106B fibrils in humans.
“Rs1990622-A was also associated with higher TMEM106B fibril content.”
Humansneurologically-normal human donorsCA1 hippocampusn = 74
The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
Molecular neurodegenerationSep 19, 2023

More on RS1990622-A

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1 paper in 12 months

Brain PathologyApr 7

Associations between TMEM106B C-terminal fragment aggregation, age, and TDP-43 or tau pathology

Cross-sectional study in peopleMechanisms

Life MedicineJan 28

Tracing TMEM106B fibril deposition in aging and Parkinson's disease with dementia brains

Cohort study in peopleMechanisms

Molecular NeurodegenerationSep 20

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Cohort study of 74 peopleProteostasis