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rege-1

Gene

2 papers2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Eidgenössische Technische Hochschule Zürich and 5 more
  • Model organisms2

Effects

1

DAF-16 nuclear localization

upin worms1

1 study

  1. rege-1 increases DAF-16 nuclear localization in worms.

    “knockdown of the top hits, pals-17 and rege-1, markedly attenuated the nuclear localization of DAF-16”

    Model organismsknockdown

    Genome-wide RNAi analysis in adult Caenorhabditis elegans unveils genes controlling age-related fat accumulation

    Mechanisms of ageing and development3 Jul 2025

More on DAF-16 nuclear localization

Associations

1

Senescence-associated beta-galactosidase

mixedin worms1

1 study

  1. rege-1 is associated with senescence-associated beta-galactosidase in worms.

    “rege-1/Regnase-1/ZC3H12A/MCPIP1, modulating β-gal staining via the transcription factor ets-4/SPDEF”

    Model organisms

    In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

    GeroScience29 Aug 2023

More on Senescence-associated beta-galactosidase

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