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PRELAMINA

There are 4 papers on PRELAMINA in aging research: 1 observational study in people, 2 in animals, 1 in cells.

Gene

4 papers study it6 findings

See all 4 papers on PRELAMINA

At a glance

The findings reach mice, none yet in people. 4 independent labs in 3 countries.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 4 independent labs in 3 countries
  • Funders: British Heart Foundation and 8 more
  • Humans1
  • Animals2
  • Cells1

Effects

5

Inflammation

upin mice1

1 study

  1. PRELAMINA increases inflammation in inducible mouse model.

    “Expression of PLA in vivo induced loss of heterochromatin and promoted inflammation and osteogenic differentiation which preceded aging indices”

    Animalsin inducible mouse model

    Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification

    Circulation research

More on Inflammation

Chromatin and 3D genome organization

downin cells1

1 study

  1. PRELAMINA decreases chromatin and 3D genome organization in vascular smooth muscle cells and vessels.

    “depletion of the repressive heterochromatin marks, H3K9me3 (histone H3, lysine 9, trimethylation) and H3K27me3 (histone H3, lysine 27,trimethylation), is an early hallmark of vascular aging”

    Cellsin vascular smooth muscle cells and vessels

    Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification

    Circulation research

More on Chromatin and 3D genome organization

Premature aging

upin mice1

1 study

  1. PRELAMINA induces premature aging in mice (through mTOR overactivation and impaired autophagy).

    “We find that accumulation of prelamin A induces premature aging through mTOR overactivation and impaired autophagy in newborn Zmpste24-/- mice.”

    Animalsthrough mTOR overactivation and impaired autophagy

    Accumulation of prelamin A induces premature aging through mTOR overactivation

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

CK2KINASEACTIVITY

downin mouse cells1

1 study

  1. PRELAMINA decreases CK2KINASEACTIVITY in Zmpste24-deficient MEFs.

    “prelamin A that accumulates in Zmpste24-deficent MEFs exhibits a high CK2α binding affinity and concomitantly reduces CK2 kinase activity”

    Cellsin Zmpste24-deficient MEFs

    Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model

    Science advances

More on CK2KINASEACTIVITY

Tumor initiation and growth

no changein mice1

1 study

  1. PRELAMINA showed no clear effect on tumor initiation and growth in Zmpste24 mosaic mice.

    “prelamin A accumulation does not impair tumour initiation and growth”

    Animalsin Zmpste24 mosaic mice

    Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

    Nature communications

Associations

1

Infiltrating oral carcinomas

downin mice1

1 study

  1. PRELAMINA lowers the risk of infiltrating oral carcinomas in Zmpste24 mosaic mice.

    “it decreases the incidence of infiltrating oral carcinomas”

    Animalsin Zmpste24 mosaic mice

    Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

    Nature communications

More on Infiltrating oral carcinomas

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