PPP2CA

7 papers1 finding

HGNC NCBI Gene Taxon

1 lab in 2 countries

Funders: China Postdoctoral Science Foundation and 2 more

Animals6
Cells1

Effects

1

Cognitive function

is required forin mice1

1 study

PPP2CA is required for cognitive function in mice.
“Hippocampal-specific PP2A knockdown diminished the beneficial effects of running, indicating that PP2A is downstream of adiponectin's action.”
Animalsshown by hippocampal knockdown of PP2A during runninghippocampus
The Adiponectin-PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress-Induced Tau Hyperphosphorylation in the Hippocampus
Aging cell1 Mar 2026

Latest

3 in 12 months

Cellular Oncology8 Jun

Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells

Experiments in human cellsCellular senescence

Free Radical Biology & Medicine8 May

Polystyrene nanoplastics drive neuronal senescence via PP2A-B56γ-targeted p-Ebp1Ser335 dephosphorylation-mediated ribosome biogenesis dysfunction

Experiments in miceCellular senescence

Aging Cell17 Mar

The Adiponectin-PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress-Induced Tau Hyperphosphorylation in the Hippocampus

Experiments in miceExercise

Environmental Pollution4 Aug

Microcystin-LR facilitates pubertal bone retardation by interfering with glutamine metabolism to accelerate stem cell senescence through Hippo/GLS pathway

Experiments in miceAmino acid metabolism

Journal of Molecular Medicine15 Nov

Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance

Experiments in miceInflammation

Antioxidants & Redox Signaling6 Mar

A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging

Experiments in miceOxidative stress and ROS signalling

Archives of Gerontology and Geriatrics24 Jun

Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8

Experiments in miceFOXO1