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POT1B

Gene

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 2 more
  • Animals2

Effects

2

Multilineage reconstitution

is required forin mice1

1 study

  1. POT1B is required for multilineage reconstitution in mice.

    “BM from Pot1b(Δ/Δ) mice cannot compete with BM from wild-type mice to provide multilineage reconstitution”

    AnimalsPot1b(Δ/Δ) vs wild-type BMbone marrow

    Essential roles for Pot1b in HSC self-renewal and survival

    Blood23 Sep 2011

Apoptosis

downin mice1

1 study

  1. POT1B prevents apoptosis in mice.

    “Deletion of Pot1b results in increased apoptosis, leading to severe depletion of the HSC reserve.”

    Animalsdeletion of Pot1b

    Essential roles for Pot1b in HSC self-renewal and survival

    Blood23 Sep 2011

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