PARK7

1. PARK7 protects against mitochondrion.

   “safeguards energy metabolism by maintaining mitochondrial structure and function”

   Reviewskeletal muscle

   Molecular Mechanisms and Therapeutic Potential of DJ-1 in Skeletal Muscle Homeostasis and Disease

   Comprehensive physiology·1 Feb 2026

1. PARK7 activates NRF2–KEAP1 antioxidant response.

   “enhances antioxidant capacity by directly scavenging ROS and regulating Nrf2/ARE signaling”

   Reviewskeletal muscle

   Molecular Mechanisms and Therapeutic Potential of DJ-1 in Skeletal Muscle Homeostasis and Disease

   Comprehensive physiology·1 Feb 2026

More on NRF2–KEAP1 antioxidant response

1. PARK7 protects against proteostasis.

   “delays muscle aging by inhibiting protein aggregation and preserving protein homeostasis”

   Reviewskeletal muscle

   Molecular Mechanisms and Therapeutic Potential of DJ-1 in Skeletal Muscle Homeostasis and Disease

   Comprehensive physiology·1 Feb 2026

More on Proteostasis

1. PARK7 decreases α-synuclein aggregation.

   “DJ-1 loss or mutation weakens antioxidant defences, promotes α-synuclein aggregation, and worsens dopaminergic neuron loss”

   ReviewEvidence discussed from DJ-1 loss or mutation

   DJ-1 in the Neuro-cutaneous Aging Axis: Unifying Pathways of Parkinson's Disease Neurodegeneration, Progression, and Redox-Based Therapeutic Strategies for Healthy Longevity

   Molecular neurobiology·1 Jan 2026

1. PARK7 decreases neuroinflammation.

   “DJ-1 (PARK7), a redox-sensitive protein, provides central neuroprotection by preserving mitochondrial integrity, mitigating oxidative stress, and curbing neuroinflammation.”

   ReviewParkinson's disease

   DJ-1 in the Neuro-cutaneous Aging Axis: Unifying Pathways of Parkinson's Disease Neurodegeneration, Progression, and Redox-Based Therapeutic Strategies for Healthy Longevity

   Molecular neurobiology·1 Jan 2026

1. PARK7 decreases oxidative stress and ROS signalling.

   “DJ-1 (PARK7), a redox-sensitive protein, provides central neuroprotection by preserving mitochondrial integrity, mitigating oxidative stress, and curbing neuroinflammation.”

   ReviewParkinson's disease

   DJ-1 in the Neuro-cutaneous Aging Axis: Unifying Pathways of Parkinson's Disease Neurodegeneration, Progression, and Redox-Based Therapeutic Strategies for Healthy Longevity

   Molecular neurobiology·1 Jan 2026

More on Oxidative stress and ROS signalling