Biology of Aging I Antisense Oligonucleotide-Mediated SRF Reduction Ameliorates Mitochondrial Dysfunction in Cardiac Aging

Abstract

Cardiac aging is characterized by progressive mitochondrial dysfunction, contributing to heart failure and other age-related cardiovascular diseases. Serum response factor (SRF) is a key transcription factor regulating cardiac integrity, but its elevated expression in aging myocardium worsens mitochondrial dysfunction and heart pathology.