NFKBIZ

1. NFKBIZ increases EHF in human cells.

   “knockdown of NFKBIZ , which encodes IκBζ and is induced downstream of NF-κB signaling, reduced EHF expression during senescence”

   Cellsdownstream of NF-κB signaling during senescence

   The Ets family transcription factor EHF suppresses senescence-associated inflammatory responses

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 1, 2026Preprint

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1. NFKBIZ activates senescence-associated secretory phenotype (SASP) in cells.

   “IκB-ζ, the principal mediator downstream of NF-κB, which regulates expression of RANKL, inflammatory, catabolic, and SASP genes.”

   Cellsdownstream of NF-κB in chondrocytes

   IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology

   Bone research·Feb 11, 2022

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