EHF

1. EHF inhibits senescence-associated secretory phenotype (SASP) in human cells.

   “EHF knockdown did not substantially affect senescence establishment but increased SASP-related gene expression.”

   Cellsin human fibroblasts undergoing oncogene-induced senescence

   The Ets family transcription factor EHF suppresses senescence-associated inflammatory responses

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 1, 2026Preprint

More on Senescence-associated secretory phenotype (SASP)

1. NFKBIZ increases EHF in human cells.

   “knockdown of NFKBIZ , which encodes IκBζ and is induced downstream of NF-κB signaling, reduced EHF expression during senescence”

   Cellsdownstream of NF-κB signaling during senescence

   The Ets family transcription factor EHF suppresses senescence-associated inflammatory responses

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 1, 2026Preprint

More on NFKBIZ