NDUFS2
- 1 lab in 1 country
- Funders: American Thoracic Society and 6 more
- Animals1
- In silico2
Effects
3Healthspan
no changein mice1
1 study
Healthspan
no changein mice1
NDUFS2 has no effect on healthspan in mice (50% decline in mRNA).
“a 50% decline in mRNA of the core mitochondrial complex I subunit Ndufs2 is neither beneficial nor detrimental to healthspan”
AnimalsNdufs2+/- hemizygous mice
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
Scientific reports25 Mar 2022
Oxidative phosphorylation
no changein mice1
1 study
Oxidative phosphorylation
no changein mice1
NDUFS2 has no effect on oxidative phosphorylation in mice.
“the mice do not demonstrate a significant decrease in complex I function”
AnimalsNdufs2+/- hemizygous mice
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
Scientific reports25 Mar 2022
Motor function
no changein mice1
1 study
Motor function
no changein mice1
NDUFS2 has no effect on motor function in mice.
“show no overt impairment in aging-related motor function, learning, tissue histology, organismal metabolism, or sensitivity to metformin”
AnimalsNdufs2+/- hemizygous mice
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
Scientific reports25 Mar 2022
Latest
2 in 12 monthsScientific Reports
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
Experiments in miceMitochondrion