MPV17

1. MPV17 protects against cochlear sensory epithelia degeneration in mice.

   “Concomitant degeneration of cochlear sensory epithelia was reported as well.”

   Animalsshown by knockout

   Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice

   Human molecular genetics·Sep 24, 2008

1. MPV17 protects against focal segmental glomerulosclerosis in mice.

   “18-month or older mice developed focal segmental glomerulosclerosis (FSGS) with massive proteinuria.”

   Animalsshown by knockout

   Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice

   Human molecular genetics·Sep 24, 2008

More on Focal segmental glomerulosclerosis

1. MPV17 increases mitochondrial DNA maintenance in mice.

   “We found severe mtDNA depletion in liver and, albeit to a lesser extent, in skeletal muscle”

   Animalsshown by knockoutliver

   Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice

   Human molecular genetics·Sep 24, 2008

More on Mitochondrial DNA maintenance