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TYMP

Gene

4 papers study it2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Agence Nationale de la Recherche and 7 more
  • 1 of 2 findings with company ties
  • Humans3

Effects

2

Liver fibrosis

downin mice1

1 study

  1. TYMP decreases liver fibrosis in mice.

    “inhibiting TP in Smo+ hepatocytes had the opposite effect and exacerbated hepatocyte senescence, steatohepatitis, and fibrosis in CDA-HFD-fed mice.”

    Animalsin CDA-HFD-fed miceliver

    The senescence-associated secretome of Hedgehog-deficient hepatocytes drives MASLD progression

    The Journal of clinical investigationAug 27, 2024

Adipocyte differentiation

is required forin human cells1

1 study

  1. TYMP is required for adipocyte differentiation in human cells.

    “CRISPR-Cas9-mediated TP KO in ASC abolished adipocyte differentiation”

    Cellsin human adipose stem cells

    Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes

    BMC medicineMar 28, 2022

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