MMP14

  • 1 lab
  • Animals1

Effects

3

Neutrophil-driven osteoblast attrition

downin mice1

1 study
  1. MMP14 protects against neutrophil-driven osteoblast attrition in mice.

    AnimalsShown by conditional Mmp14 deletion in the chondrocyte-osteoblast lineagebone

    Loss of a matrix enzyme triggers adult bone loss in mice

    Research Square9 Oct 2026Preprint

Skeletal progenitor depletion

downin mice1

1 study
  1. MMP14 protects against skeletal progenitor depletion in mice.

    AnimalsShown by conditional Mmp14 deletion in the chondrocyte-osteoblast lineagebone

    Loss of a matrix enzyme triggers adult bone loss in mice

    Research Square9 Oct 2026Preprint

Osteopenia

downin mice1

1 study
  1. MMP14 protects against osteopenia in mice.

    AnimalsShown by conditional Mmp14 deletion in the chondrocyte-osteoblast lineagebone

    Loss of a matrix enzyme triggers adult bone loss in mice

    Research Square9 Oct 2026Preprint

More on Osteopenia

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 in 12 months
Research Square

Loss of a matrix enzyme triggers adult bone loss in mice

Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.

Preprint: experiments in miceBones and joints