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MIR33

Gene

4 papers study it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals1
  • Cells3

Effects

3

Cholesterol efflux

downin mouse cells1

1 study

  1. MIR33 decreases cholesterol efflux in mouse cells.

    “pre-miR-33a attenuated cholesterol efflux induced by UA.”

    Cellsin ox-LDL-treated RAW264.7 cells

    Urolithin A attenuated ox-LDL-induced cholesterol accumulation in macrophages partly through regulating miR-33a and ERK/AMPK/SREBP1 signaling pathways

    Food & function

More on Cholesterol efflux

CDK6

downin mouse cells1

1 study

  1. MIR33 inhibits CDK6 in mouse cells.

    “our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.”

    Cellsembryonic fibroblast

    MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6

    Biochemical and biophysical research communications

More on CDK6

Cellular senescence

upin mouse cells1

1 study

  1. MIR33 increases cellular senescence in mouse cells.

    “ectopic expression of microRNA-33 promoted MEFs senescence, while knock-down of microRNA-33 exhibited a protective effect against senescence phenotype.”

    CellsEctopic expression and knockdown of microRNA-33embryonic fibroblast

    MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6

    Biochemical and biophysical research communications

More on Cellular senescence

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