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LYN

Gene

2 papers1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 28 trials, 23 with no results posted
  • Funders: Medical Research Council and 1 more
  • 28 of 28 trials sponsored by developers of drugs on it
  • Animals1
  • Cells1

Effects

1

Lifespan

upin mice1

1 study

  1. LYN extends lifespan in mice (1016 days vs 890 days).

    “The extended lifespan is evident in the Box1-mutant males (retains Lyn activation), which have a median lifespan of 1016 days compared to 890 days for the Ghr-/- males.”

    Animalsmales

    Roles of Growth Hormone-Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence

    Endocrinology26 Sep 2024

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