HIPK3

HIPK3 decreases aging-related cardiac phenotypes in mice.

“Conversely, circHIPK3 overexpression restored Ncl expression, rescued LLPS and ribosome biogenesis defects, and alleviated aging-related cardiac phenotypes in vitro and in vivo.”

AnimalscircHIPK3 overexpressionheart

circHIPK3 Sustains Ribosome Biogenesis and Protects Against Cardiac Aging by Stabilizing Ncl mRNA and Supporting its LLPS

Aging and disease·12 May 2026

HIPK3 increases ribosome biogenesis in mice.

“circHIPK3 deficiency is accompanied by altered Ncl LLPS dynamics, reduced ribosomal RNA synthesis and ribosomal protein expression, and impaired de novo ribosome production.”

Animalsshown by circHIPK3 deficiencyheart

circHIPK3 Sustains Ribosome Biogenesis and Protects Against Cardiac Aging by Stabilizing Ncl mRNA and Supporting its LLPS

Aging and disease·12 May 2026

HIPK3 improves cardiac function in mice.

“We generated cardiomyocyte-specific circHIPK3 knockout (CKO) mice, and found that these mice exhibited cardiac aging phenotypes, cardiac dysfunction, hypertrophy, and fibrosis.”

Animalsshown by cardiomyocyte-specific circHIPK3 knockoutheart

circHIPK3 Sustains Ribosome Biogenesis and Protects Against Cardiac Aging by Stabilizing Ncl mRNA and Supporting its LLPS

Aging and disease·12 May 2026