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GATD3A

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Nanjing Medical University and 1 more
  • Animals1

Effects

2

MDH2 activity

upin mouse cells1

1 study

  1. GATD3A increases MDH2 activity in mouse cells.

    “GATD3A deficiency enhances the binding of Sirt3 to MDH2, leading to deacetylation and decreased activity of MDH2.”

    Cellsshown by GATD3A deficiency; enhanced Sirt3 binding and MDH2 deacetylationfibroblast-like synoviocyte

    GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression

    Nature communications30 Dec 2024

More on MDH2 activity

Cellular senescence

downin mouse cells1

1 study

  1. GATD3A inhibits cellular senescence in mouse cells.

    “GATD3A deficiency induces fibroblast-like synoviocyte senescence.”

    Cellsshown by GATD3A deficiencyfibroblast-like synoviocyte

    GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression

    Nature communications30 Dec 2024

More on Cellular senescence

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