MDH2 activity

1. GATD3A increases MDH2 activity in mouse cells.

   “GATD3A deficiency enhances the binding of Sirt3 to MDH2, leading to deacetylation and decreased activity of MDH2.”

   Cellsshown by GATD3A deficiency; enhanced Sirt3 binding and MDH2 deacetylationfibroblast-like synoviocyte

   GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression

   Nature communications·30 Dec 2024

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