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GATA6

Gene

4 papers study it7 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 3 independent labs in 3 countries
  • Funders: China Scholarship Council and others
  • Animals1
  • Model organisms1
  • Cells2

Effects

5

DNA repair

downin cells1

1 study

  1. GATA6 inhibits DNA repair in cells.

    “GATA6 was induced by DNA damage stress during arterial calcification and subsequently impeded the Ataxia-telangiectasia mutated (ATM)-mediated DNA damage repair process”

    Cellsduring arterial calcification

    The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair

    Kidney internationalOct 31, 2023

More on DNA repair

Cellular senescence

upin cells1

1 study

  1. GATA6 increases cellular senescence in cells.

    “Calcified aortas displayed senescent features with VSMCs undergoing premature senescence, blunted by GATA6 downregulation.”

    Cellsaorta

    The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair

    Kidney internationalOct 31, 2023

More on Cellular senescence

Arterial calcification

upin mice1

1 study

  1. GATA6 increases arterial calcification in mice.

    “Knockdown of GATA6, via recombinant adeno-associated virus carrying GATA6 shRNA, inhibited the development of arterial calcification in mice with CKD.”

    Animalsin mice with CKD

    The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair

    Kidney internationalOct 31, 2023

More on Arterial calcification

Healthy aging

upin humans1

1 study

  1. GATA6 improves healthy aging in humans.

    “GATA 6, Yamanaka factors, and FOLR1 work in synchronization to induce healthy and delayed aging.”

    Review

    Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging

    BiomedicinesJan 26, 2023

Amyloid-β proteotoxicity

downin mammals cells1

1 study

  1. GATA6 decreases amyloid-β proteotoxicity in mammals cells.

    “Overexpression of GATA4/GATA6 alleviates amyloid-β proteotoxicity in mammalian cells”

    CellsGATA6 overexpressionmammalian cell

    A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan

    bioRxiv (Cold Spring Harbor Laboratory)Jun 14, 2022Preprint

Upstream

1

SIRT6

downin mice1

1 study

  1. SIRT6 inhibits GATA6 in mice.

    “abnormal induction of GATA6 in senescent and calcified aortas was rescued in Sirtuin 6 (SIRT6)-transgenic mice”

    Animalsin senescent and calcified aortas of transgenic mice

    The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair

    Kidney internationalOct 31, 2023

More on SIRT6

Associations

1

CD274

mixedin human cells1

1 study

  1. GATA6 is associated with CD274 in human cells.

    “both suppressors of cytokine signaling 3 (SOCS3) and interleukin 6 were involved in GATA6-induced regulation, collectively affecting the expression of programmed death ligand 1 (PDL1)”

    Cellstarget gene knockdown

    Advancing immunomodulatory functions in mesenchymal stem/stromal cells through targeting the GATA6-mediated pathway

    CytotherapyAug 8, 2024

More on CD274

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